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  • 7 Similar Profiles
HIV-1 Medicine & Life Sciences
RNA Medicine & Life Sciences
HIV Medicine & Life Sciences
tat Gene Products Medicine & Life Sciences
Positive Transcriptional Elongation Factor B Medicine & Life Sciences
HIV Long Terminal Repeat Medicine & Life Sciences
Response Elements Medicine & Life Sciences
Proviruses Medicine & Life Sciences

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Projects 1994 2021

Reversal of HIV latency by METH and Inflammation

Karn, J.

National Institutes of Health

9/1/166/30/21

Project: Research projectResearch Project

Methamphetamine
HIV
Inflammation
Microglia
Street Drugs
HIV-1
HIV
Brain
Virus Latency
Viral Proteins
Lymphoid Tissue
Natural Killer Cells
HIV
Mouth
Infection

HIV eradication by ADCC-activated NK cell killing

Karn, J.

National Institutes of Health

12/1/132/28/19

Project: Research projectExploratory/Developmental Grants, Exploratory/Developmental Grants Phase II

Antibody-Dependent Cell Cytotoxicity
HIV Antibodies
Natural Killer Cells
HIV
T-Lymphocyte Subsets

AIDS RESEARCH

Chance, M. R., McDonald, D., Kaplan, D. R., Lederman, M. M., Toossi, Z., Arts, E. J., siegel, S. F., Karn, J., Boom, W. H., Skowronski, J., McGrath, J., Nankya, I. L., Merrick, W., Le-Grice, S., Whalen, C., Renne, R., Rodriguez, B., Remick, S., Leis, J., Boom, H., Ellner, J., Rich, E., Merrick, W. C., Salata, R. A., Skowronski, J. & Popkin, D.

National Institutes of Health

4/1/944/30/20

Project: Research projectCenter Core Grants

Research
AIDS
Acquired Immunodeficiency Syndrome
HIV
Research Personnel

Research Output 1973 2018

  • 9121 Citations
  • 54 h-Index
  • 112 Article
  • 3 Review article
  • 2 Chapter
  • 1 Comment/debate
1 Citations

Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation

Mbonye, U., Wang, B., Gokulrangan, G., Shi, W., Yang, S. & Karn, J., Jan 1 2018, In : Journal of Biological Chemistry. 293, 26, p. 10009-10025 17 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 9
Positive Transcriptional Elongation Factor B
Phosphorylation
Cyclin-Dependent Kinases
Cyclin T
2 Citations

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir

Das, B., Dobrowolski, C., Luttge, B., Valadkhan, S., Chomont, N., Johnston, R., Bacchetti, P., Hoh, R., Gandhi, M., Deeks, S. G., Scully, E. & Karn, J., Aug 14 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 33, p. E7795-E7804

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Estrogen Receptor alpha
HIV-1
Hydroxamic Acids
Interleukin-15

Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA

Chen, L., Feng, Z., Yue, H., Bazdar, D., Mbonye, U., Zender, C. A., Harding, C. V., Bruggeman, L. A., Karn, J., Sieg, S. F., Wang, B. & Jin, G., Dec 1 2018, In : Nature communications. 9, 1, 4585.

Research output: Contribution to journalArticle

Exosomes
human immunodeficiency virus
T-cells
gene expression
Toll-Like Receptor 3
1 Citations

The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells

Alvarez-Carbonell, D., Ye, F., Ramanath, N., Dobrowolski, C. & Karn, J., Jul 10 2018, (Accepted/In press) In : Journal of NeuroImmune Pharmacology. p. 1-16 16 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
HIV
Dexamethasone
Microglia
Tumor Necrosis Factor-alpha

The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency

Li, Z., Mbonye, U., Feng, Z., Wang, X., Gao, X., Karn, J. & Zhou, Q., Apr 1 2018, In : PLoS Pathogens. 14, 4, e1007012.

Research output: Contribution to journalArticle

Virus Latency
HIV-1
HIV
Proviruses
Positive Transcriptional Elongation Factor B

Press/Media

Scientists Look to Epigenetics to Thwart Viruses

Jonathan Karn

9/1/17

2 items of media coverage

Press/Media: Press / Media

Can a Novel Combination of Treatments Help Eradicate HIV?

Michael Marcel Lederman & Jonathan Karn

1/31/172/16/17

5 items of media coverage

Press/Media: Press / Media

October 21, 2015

Jonathan Karn

9/12/16

1 item of media coverage

Press/Media: Press / Media

Case Western Reserve researcher awarded Drexel Prize in Translational Medicine

Jonathan Karn

9/6/169/7/16

4 items of media coverage

Press/Media: Press / Media