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  • 9 Similar Profiles
decitabine Medicine & Life Sciences
Myelodysplastic Syndromes Medicine & Life Sciences
Sickle Cell Anemia Medicine & Life Sciences
Acute Myeloid Leukemia Medicine & Life Sciences
Fetal Hemoglobin Medicine & Life Sciences
Azacitidine Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Epigenomics Medicine & Life Sciences

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Projects 2008 2021

Imaging Liver Cancer Proliferation

Lee, Z. & Saunthararajah, Y.

National Institutes of Health

8/15/167/31/21

Project: Research projectResearch Project

Liver Neoplasms
Hepatocellular Carcinoma
Deoxycytidine Kinase
Liver
Cytidine Deaminase

Improving HbF induction by inhibiting epigenetic target enzymes

Saunthararajah, Y., Desimone, J. & Engel, J. D.

National Institutes of Health

8/15/135/31/18

Project: Research projectResearch Project--Cooperative Agreements

Epigenomics
Sickle Cell Anemia
Enzymes
Pharmaceutical Preparations
Globins
decitabine
Leukemia
Cytidine Deaminase
Hematopoietic Stem Cells
Stem Cells

Chicago Comprehensive Sickle Cell Center: Basic &Translational Research Program

Saunthararajah, Y., Gallo, A. M. & Desimone, J.

National Institutes of Health

6/18/083/31/12

Project: Research projectSpecialized Center--Cooperative Agreements

Cellular Structures
Sickle Cell Anemia
decitabine
Manuscripts
Research

Research Output 1999 2018

  • 5145 Citations
  • 36 h-Index
  • 113 Article
  • 5 Chapter
  • 2 Review article
  • 1 Comment/debate
1 Citations

A novel L-asparaginase with low L-glutaminase coactivity is highly efficacious against both T- and B-cell acute lymphoblastic Leukemias In Vivo

Nguyen, H. A., Su, Y., Zhang, J. Y., Antanasijevic, A., Caffrey, M., Schalk, A. M., Liu, L., Rondelli, D., Oh, A., Mahmud, D. L., Bosland, M. C., Kajdacsy-Balla, A., Peirs, S., Lammens, T., Mondelaers, V., De Moerloose, B., Goossens, S., Schlicht, M. J., Kabirov, K. K., Lyubimov, A. V. & 4 othersMerrill, B. J., Saunthararajah, Y., Van Vlierberghe, P. & Lavie, A., Mar 15 2018, In : Cancer Research. 78, 6, p. 1549-1560 12 p.

Research output: Contribution to journalArticle

Biphenotypic Acute Leukemia
Glutaminase
Asparaginase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
glutamin-(asparagin-)ase

Beta-thalassemia minor manifesting as proliferative retinopathy

Stultz, R. D., Conti, F. F., Kumar, J. B., Kotabish, E., Schachat, A., Ehlers, J. P., Saunthararajah, Y. & Singh, R. P., Oct 1 2018, In : Ophthalmic Surgery Lasers and Imaging Retina. 49, 10, p. e161-e164

Research output: Contribution to journalArticle

beta-Thalassemia
beta-Globins
Pathology
Vitreous Hemorrhage
Retinal Diseases

Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells

Enane, F. O., Saunthararajah, Y. & Korc, M., Sep 1 2018, In : Cell Death and Disease. 9, 9, 912.

Research output: Contribution to journalReview article

Cell Proliferation
Co-Repressor Proteins
Neoplasms
Apoptosis
Genes

Fetal Hemoglobin Induction by Epigenetic Drugs

Lavelle, D., Engel, J. D. & Saunthararajah, Y., Jan 1 2018, (Accepted/In press) In : Seminars in Hematology.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Sickle Cell Anemia
Epigenomics
Histone-Lysine N-Methyltransferase
Protein-Arginine N-Methyltransferases
1 Citations

Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates

Gu, X., Ebrahem, Q., Mahfouz, R. Z., Hasipek, M., Enane, F., Radivoyevitch, T., Rapin, N., Przychodzen, B., Hu, Z., Balusu, R., Cotta, C. V., Wald, D. N., Argueta, C., Landesman, Y., Martelli, M. P., Falini, B., Carraway, H. E., Porse, B. T., Maciejewski, J. P., Jha, B. K. & 1 othersSaunthararajah, Y., Oct 1 2018, In : Journal of Clinical Investigation. 128, 10, p. 4260-4279 20 p.

Research output: Contribution to journalArticle

Monocytes
Co-Repressor Proteins
Transcription Factors
decitabine
Granulocytes

Press/Media