Bifurcation of the respiratory response to lung inflation in anesthetized dogs

Jaroslaw R. Romaniuk, Thomas E. Dick, Eugene N. Bruce, Anthony F. DiMarco, Krzysztof E. Kowalski

Research output: Contribution to journalArticle

Abstract

Numerous studies have demonstrated the effect of lung volume on prolongation of duration of expiration (TE) with limited understanding of the TE shortening and termination of expiration as observed in newborn. In 14 dogs, the effects of varied onset of lung inflation during expiration on the TE were evaluated. When lung inflation was applied in the first part of expiration (20–60% of TE) TE was lengthened. However, in the second portion (60–80% of TE) of expiration, lung inflation either terminated or prolonged TE; whereas in the last portion of expiration (80–90% of TE), lung inflation tended to terminate expiration prematurely. The effects were abolished after bilateral vagotomy. We postulate that prolongation of TE relates to the Breuer-Hering inflation reflex, which increases the time needed for a passive expiration; whereas the ability to shorten TE could relate to Head's paradoxical reflex acting to initiate inspiration or to activate inspiratory motor activity to brake expiratory flow as occurs in the newborn.

Original languageEnglish (US)
Pages (from-to)26-31
Number of pages6
JournalRespiratory Physiology and Neurobiology
Volume244
DOIs
StatePublished - Oct 1 2017

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Economic Inflation
Dogs
Lung
Reflex
Vagotomy
Motor Activity

Keywords

  • Expiratory off-switch
  • Respiration
  • Vagal reflexes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Bifurcation of the respiratory response to lung inflation in anesthetized dogs. / Romaniuk, Jaroslaw R.; Dick, Thomas E.; Bruce, Eugene N.; DiMarco, Anthony F.; Kowalski, Krzysztof E.

In: Respiratory Physiology and Neurobiology, Vol. 244, 01.10.2017, p. 26-31.

Research output: Contribution to journalArticle

Romaniuk, Jaroslaw R.; Dick, Thomas E.; Bruce, Eugene N.; DiMarco, Anthony F.; Kowalski, Krzysztof E. / Bifurcation of the respiratory response to lung inflation in anesthetized dogs.

In: Respiratory Physiology and Neurobiology, Vol. 244, 01.10.2017, p. 26-31.

Research output: Contribution to journalArticle

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