Blockade of dorsolateral pontine 5HT1A receptors destabilizes the respiratory rhythm in C57BL6/J wild-type mice

R. R. Dhingra, M. Dutschmann, T. E. Dick

Research output: Contribution to journalArticle

  • 2 Citations

Abstract

The neurotransmitter serotonin (5HT) acting via 5HT1a receptors (5HT1aR) is a potent determinant of respiratory rhythm variability. Here, we address the 5HT1aR-dependent control of respiratory rhythm variability in C57BL6/J mice. Using the in situ perfused preparation, we compared the effects of systemic versus focal blockade of 5HT1aRs. Blocking 5HT1aRs in the Kölliker-Fuse nucleus (KFn) increased the occurrence of spontaneous apneas and accounted for the systemic effects of 5HT1aR antagonists. Further, 5HT1aRs of the KFn stabilized the respiratory rhythm's response to arterial chemoreflex perturbations; reducing the recovering time, e.g., the latency to return to the baseline pattern. Together, these results suggest that the KFn regulates both intrinsic and sensory determinants of respiratory rhythm variability.

Original languageEnglish (US)
Pages (from-to)110-114
Number of pages5
JournalRespiratory Physiology and Neurobiology
Volume226
DOIs
StatePublished - Jun 1 2016

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Kolliker-Fuse Nucleus
Apnea
Neurotransmitter Agents
Serotonin

Keywords

  • Control of breathing
  • Gain control
  • Kölliker-Fuse nuclei (KFN)
  • Mecp2-deficient mice
  • Rett Syndrome
  • Serotonin (5-HT)
  • Variability

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Blockade of dorsolateral pontine 5HT1A receptors destabilizes the respiratory rhythm in C57BL6/J wild-type mice. / Dhingra, R. R.; Dutschmann, M.; Dick, T. E.

In: Respiratory Physiology and Neurobiology, Vol. 226, 01.06.2016, p. 110-114.

Research output: Contribution to journalArticle

Dhingra, R. R.; Dutschmann, M.; Dick, T. E. / Blockade of dorsolateral pontine 5HT1A receptors destabilizes the respiratory rhythm in C57BL6/J wild-type mice.

In: Respiratory Physiology and Neurobiology, Vol. 226, 01.06.2016, p. 110-114.

Research output: Contribution to journalArticle

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