Electrical stimulation of a small brain area reversibly disrupts consciousness

Mohamad Z. Koubeissi, Fabrice Bartolomei, Abdelrahman Beltagy, Fabienne Picard

Research output: Contribution to journalArticle

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Abstract

The neural mechanisms that underlie consciousness are not fully understood. We describe a region in the human brain where electrical stimulation reproducibly disrupted consciousness. A 54-year-old woman with intractable epilepsy underwent depth electrode implantation and electrical stimulation mapping. The electrode whose stimulation disrupted consciousness was between the left claustrum and anterior-dorsal insula. Stimulation of electrodes within 5mm did not affect consciousness. We studied the interdependencies among depth recording signals as a function of time by nonlinear regression analysis (h2 coefficient) during stimulations that altered consciousness and stimulations of the same electrode at lower current intensities that were asymptomatic. Stimulation of the claustral electrode reproducibly resulted in a complete arrest of volitional behavior, unresponsiveness, and amnesia without negative motor symptoms or mere aphasia. The disruption of consciousness did not outlast the stimulation and occurred without any epileptiform discharges. We found a significant increase in correlation for interactions affecting medial parietal and posterior frontal channels during stimulations that disrupted consciousness compared with those that did not. Our findings suggest that the left claustrum/anterior insula is an important part of a network that subserves consciousness and that disruption of consciousness is related to increased EEG signal synchrony within frontal-parietal networks.

LanguageEnglish (US)
Pages32-35
Number of pages4
JournalEpilepsy and Behavior
Volume37
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Consciousness
Electric Stimulation
Brain
Electrodes
Basal Ganglia
Deep Brain Stimulation
Amnesia
Aphasia
Electroencephalography
Regression Analysis

Keywords

  • Claustrum
  • Consciousness
  • Electrical stimulation
  • Epilepsy
  • Insula

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Electrical stimulation of a small brain area reversibly disrupts consciousness. / Koubeissi, Mohamad Z.; Bartolomei, Fabrice; Beltagy, Abdelrahman; Picard, Fabienne.

In: Epilepsy and Behavior, Vol. 37, 2014, p. 32-35.

Research output: Contribution to journalArticle

Koubeissi, Mohamad Z. ; Bartolomei, Fabrice ; Beltagy, Abdelrahman ; Picard, Fabienne. / Electrical stimulation of a small brain area reversibly disrupts consciousness. In: Epilepsy and Behavior. 2014 ; Vol. 37. pp. 32-35
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